The acute phase response inhibits reverse cholesterol transport

The acute phase response inhibits reverse cholesterol transport.

Tachometer for Reverse Cholesterol Transport?

M any clinical and epidemiological studies, as well as meta-analyses thereof, have shown the inverse relationship of high-density lipoprotein cholesterol (HDL-C) and apoliopoprotein (apo) A-I plasma levels with the risk of coronary artery disease. HDL particles and their protein and lipid components exert diverse antioxidative, antiinflammatory, antithrombotic, and cytoprotective effects in vit...

Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption.

RATIONALE Psychological stress is associated with an increased risk of cardiovascular diseases. However, the connecting mechanisms of the stress-inducing activation of the hypothalamic-pituitary-adrenal axis with atherosclerosis are not well-understood. OBJECTIVE To study the effect of acute psychological stress on reverse cholesterol transport (RCT), which transfers peripheral cholesterol to...

Reverse cholesterol transport and atherosclerosis regression.

Cholesterol is the major component of atherosclerotic plaque. Cholesterol accumulation within atherosclerotic plaque occurs when cholesterol influx into the arterial wall (from apoB-containing lipoproteins) exceeds cholesterol efflux. Increased influx of cholesterol into the arterial wall is accompanied by an increased influx of monocytes/macrophages,1 which take up oxidized and aggregated LDL ...

A New Frontier for Reverse Cholesterol Transport

Numerous epidemiological studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with cardiovascular risk. However, despite intense efforts to develop new pharmacological strategies to increase HDL-C levels, such as with niacin and cholesteryl ester transfer protein inhibitors, few robust associations with improved clinical outcomes have been ...